Identifying the Neural Signature of Healthy Brain Aging

Younger people efficiently engage brain processes necessary to perform a task, while at the same time “shut down” processes irrelevant to the task, according to new research from the Center for Vital Longevity (CVL) at UT Dallas.

In addition, this ability to modulate, or control, brain activity appears compromised in older adults, said Dr. Kristen Kennedy, assistant professor at the center and the School of Behavioral and Brain Sciences.

“To use a car analogy, the ‘neuroflexibility’ involved in pressing on the gas to meet a cognitive task, while simultaneously tapping on the brakes on anything that doesn’t help you get to the finish line of a task at hand, is one of the neural phenomena we’ve singled out,” said Kennedy, who led the research published in the February issue of NeuroImage.

By tracking the patterns of “neuroflexibility” and how more flexibility generally correlates with better cognitive performance and vice versa, researchers may one day be able to develop a more precise diagnostic criterion for determining which middle-aged adults may be at risk of cognitive decline later in life.

The CVL findings were based on a study of 161 healthy adults ages 20 to 94 from the Dallas-Fort Worth area. Participants were given a battery of neuropsychological tests before they were placed in a functional magnetic resonance imaging (fMRI) scanner, which measures brain activity. While in the scanner, participants were then asked to perform a simple spatial distance judgment task that involved discerning whether a dot was to the left or right of a horizontal bar. A second task involved dots that were either very far from the horizontal line or increasingly near or far, representing various levels of difficulty…